I’ve used this organization plan for a few trips now and it seems optimum for my things anyway.
From the top left: a bag for all the miscellaneous electronica, walking sandals (my flips were downstairs), the computer sleeve, a bathroom bag with all the fix-me-ups, liquids and gels (there’s a quart ziplock inside the stronger one).
Bottom row: four bags including 1) swimming and dress-up outfits including shoes (a bag that doesn’t get opened often), 2) shirts (x6 in layers), 3) pants (x4) and sleep wear, 4) undies.
Sling bag not shown: camera and purse.
You need to wear all the heavy things layered on the airplane adding significantly to your wardrobe, and then there is plenty of room left in a carry-on bag to tuck in an umbrella, more socks and a hat if it’s a cold weather trip, and a few other things, but not much more.
Once off the plane the suitcase can expand to carry everything so you don’t have to wear all the heavy things for every transfer, just for the plane.